Personality Predictors of Dementia; Parkinson’s Blood Test; Klotho in Alzheimer’s

Personality traits were strong predictors of dementia diagnoses in a meta-analysis, but were not consistently associated with neuropathology at autopsy. (Alzheimer’s and Dementia)

Neuronally derived extracellular vesicle-associated alpha-synuclein in serum correctly identified 80% of at-risk people who phenoconverted to Parkinson’s disease and related dementia. (JAMA Neurology)

High-dose nicotinamide riboside eased Parkinson’s motor symptoms in a phase I trial. (Nature Communications)

Injecting allogeneic neural stem cells into the brains of people with secondary progressive multiple sclerosis was tolerated in a phase I study. (Cell Stem Cell)

Klotho protein levels differed in clinical stages of Alzheimer’s and were associated with amyloid and tau burden. (JAMA Network Open)

Newborn infants perceived the beat in music. (Cognition)

Short sleep and sleep variability were linked with impaired cognitive performance in older adults. (JAMA Network Open)

Liver fibrosis was associated with cognitive decline in Parkinson’s disease. (Journal of Clinical Neuroscience)

Blood-based biomarkers of amyloid, tau, and neurodegeneration were tied to domain-specific neuropsychological performance in women with and without HIV. (JAMA Network Open)

Microglia with the R47H/+ mutation in TREM2 protein promoted synapse loss in mice. (GLIA)

Also in mice, salty immune cells that surrounded the brain were linked with hypertension-induced dementia. (Nature Neuroscience)

A Norwegian study found a moderate association between objectively measured hearing impairment and dementia in people ages 70 to 85. (eClinicalMedicine)